The British police have urged suspects connected to the deaths of Ben Gillham-Rice and Ghanaian born British Dominic Ansah to turn themselves in.
Dominic Ansah and Ben Gillham-Rice, both 17, died from knife injuries after they were attacked at a house party in the Emerson Valley area of the town on 19th October.
After a murder investigation was launched, 21-year-old Charlie Chandler was arrested.
A 22-year-old man from Milton Keynes arrested on suspicion of murder and attempted murder on Thursday remains in police custody.
Thames Valley Police said on Friday that they believe other people were involved in the fatal incident in Archford Croft and urged them to come forward.
Jamie Chandler, aged 15, and Clayton Barker, aged 19, both from Milton Keynes, are urged to contact police as soon as possible.
Clayton Barker is also suspected to be a Ghanaian born British.
Head of Crime for Thames Valley Police, Detective Chief Superintendent Ian Hunter, said: “The public has been incredibly supportive of this investigation so far, and I am appealing once again for their help.
“We are releasing the names and images of Jamie Chandler and Clayton Barker, as we believe that they both have crucial information that will assist our investigation and we need to speak to them.
“I am appealing directly to both Jamie Chandler and Clayton Barker to make contact with police as soon as possible.
“I am also asking for the public’s help. If anybody knows the whereabouts of either Jamie Chandler or Clayton Barker, please contact the 24-hour non-emergency number.
“You can also make this report online if you wish, or call the independent charity Crimestoppers for 100% anonymity on 0800 555 111.
“If either Jamie Chandler or Clayton Barker see this appeal, or anybody is with them or knows where they are, I again reiterate the importance of getting in touch with police.
“Our investigation into the circumstances of this tragic incident continues, and I would like to thank the public for all their help so far.”